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Journal Club: Wednesdays at 1:00pm in Genentech Hall Auditorium

September 28, 2016

***Will meet in Mission Hall 1407***

Dinara Azimova
Sil Lab

"Bacillus subtilis ‘SEDS’ no to canonical model of cell wall biogenesis”

Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. 2016 Aug 15. doi: 10.1038/nature19331. [Epub ahead of print]

David Weinberg

"Presenting a new cap-binding protein: Now in 3D!”

Lee AS, Kranzusch PJ, Doudna JA, Cate JH. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature. 2016 Aug 4;536(7614):96-9.

October 5, 2016

***Will meet in Genentech Hall N114***

Matt Laurie
DeRisi Lab

"TomO Arigato Mr. Wolbacho for restoring Germ Stem Cells in Drosophila Sex-lethal Mutants.”

Ote M, Ueyama M, Yamamoto D. Wolbachia Protein TomO Targets nanos mRNA and Restores Germ Stem Cells in Drosophila Sex-lethal Mutants. Curr Biol. 2016 Sep 12;26(17):2223-32. doi: 10.1016/j.cub.2016.06.054. Epub 2016 Aug 4.

Fred Chang

"Weight fluctuations in cells: changes in cell volume and density during the cell cycle!”

Zlotek-Zlotkiewicz E, Monnier S, Cappello G, Le Berre M, Piel M. Optical volume and mass measurements show that mammalian cells swell during mitosis. J Cell Biol. 2015 Nov 23;211(4):765-74. doi: 10.1083/jcb.201505056.

October 12, 2016

***Will meet in Genentech Hall N114***

Rosa Rodriguez
Sil Lab

"The Convoluted and Elongated Story of Dengue and Membranes”

Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R. Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell Host Microbe. 2016 Sep 14;20(3):342-56. doi: 10.1016/j.chom.2016.07.008. Epub 2016 Aug 18.

Sophie Dumont

"Cell division: A sticky problem for chromosomes”
Cuylen S, Blaukopf C, Politi AZ, Müller-Reichert T, Neumann B, Poser I, Ellenberg J, Hyman AA, Gerlich DW. Ki-67 acts as a biological surfactant to disperse mitotic chromosomes. Nature. 2016 Jun 29;535(7611):308-12. doi: 10.1038/nature18610.

October 19, 2016

***Will meet in Genentech Hall N114***

Luke Strauskulage
Panning/Redding Labs

"Water they bearing? Tardigrades may have co-opted nuclear lamins to tolerate mechanical stress"

Hering L, Bouameur JE, Reichelt J, Magin TM, Mayer G. Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades. Elife. 2016 Feb 3;5:e11117. doi: 10.7554/eLife.11117.

Martin Kampmann

"A Poly Relationship for the Ages”
Cremers CM, Knoefler D, Gates S, Martin N, Dahl JU, Lempart J, Xie L, Chapman MR, Galvan V, Southworth DR, Jakob U. Polyphosphate: A Conserved Modifier of Amyloidogenic Processes. Mol Cell. 2016 Sep 1;63(5):768-80. doi: 10.1016/j.molcel.2016.07.016. Epub 2016 Aug 25.

October 26, 2016

***Will meet in Genentech Hall N114***

Isabel Johnson
Frost Lab

"Friendly fire from a molecular speargun, the Type VI Secretion System”

Vettiger A, Basler M. Type VI Secretion System Substrates Are Transferred and Reused among Sister Cells. Cell. 2016 Sep 22;167(1):99-110.e12. doi: 10.1016/j.cell.2016.08.023. Epub 2016 Sep 8.

Peter Turnbaugh

"Can you replace your gut microbiome?”

Li SS, Zhu A, Benes V, Costea PI, Hercog R, Hildebrand F, Huerta-Cepas J, Nieuwdorp M, Salojärvi J, Voigt AY, Zeller G, Sunagawa S, de Vos WM, Bork P. Durable coexistence of donor and recipient strains after fecal microbiota transplantation. Science. 2016 Apr 29;352(6285):586-9. doi: 10.1126/science.aad8852.

November 2, 2016

***Will meet in Genentech Hall N114***

Conor Howard
Frost Lab

"Can't stop won't stop? Translation without a dedicated stop codon”

Swart EC, Serra V, Petroni G, Nowacki M. Genetic Codes with No Dedicated Stop Codon: Context-Dependent Translation Termination. Cell. 2016 Jul 28;166(3):691-702. doi: 10.1016/j.cell.2016.06.020. Epub 2016 Jul 14.

Hani Goodarzi

"Fitness profiling and functional genomics”

Giaever G et al.  Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002 Jul 25;418(6896):387-91.

November 9, 2016

***Will meet in Genentech Hall N114***

Paola Soto-Perez
Turnbaugh Lab

"Feed a Cold and Starve a Fever: Grandma is Wrong!”

Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R. Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell. 2016 Sep 8;166(6):1512-1525.e12. doi: 10.1016/j.cell.2016.07.026.

David Toczyski

"One step closer to a Cyborg”

Zhu X, Liu S, Cao J, Mao X, Li G. Switchable DNA wire: deposition-stripping of copper nanoclusters as an "ON-OFF" nanoswitch. Sci Rep. 2016 Jan 19;6:19515. doi: 10.1038/srep19515.

November 16, 2016

***Will meet in Genentech Hall N114***

Lina Leon
Bondy-Denomy/Kortemme Labs

"Utilizing bacterial circuits for drug delivery”

Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, Julio E, Atolia E, Tsimring LS, Bhatia SN, Hasty J. Synchronized cycles of bacterial lysis for in vivo delivery. Nature. 2016 Aug 4;536(7614):81-5.

Todd Nystul

"Cost-benefit analysis of regeneration”

Harris RE, Setiawan L, Saul J, Hariharan IK. Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs. Elife. 2016 Feb 3;5. pii: e11588. doi: 10.7554/eLife.11588.

November 30, 2016

***Will meet in Genentech Hall N114***

Madeline Keenen
Narlikar/Redding Labs

"Molecular WeightWatchers - a eukaryotic sensor for membrane lipid saturation”

Covino R, Ballweg S, Stordeur C, Michaelis JB, Puth K, Wernig F, Bahrami A, Ernst AM, Hummer G, Ernst R. A Eukaryotic Sensor for Membrane Lipid Saturation. Mol Cell. 2016 Jul 7;63(1):49-59. doi: 10.1016/j.molcel.2016.05.015. Epub 2016 Jun 16.

Aimee Kao

"Getting the Most Out of Life”

Dong X, Milholland B, Vijg J. Evidence for a limit to human lifespan. Nature. 2016 Oct 5;538(7624):257-259. doi: 10.1038/nature19793. [Epub ahead of print]

January 18, 2017

***Will meet in Genentech Hall N114***

Mitchell Lopez
Jura Lab

"Aβating Alzheimer’s with 40Hz of freedom”

Iaccarino HF et al. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2016 Dec 7;540(7632):230-235. doi: 10.1038/nature20587.

Leor Weinberger

"A virus of a virus limits virulence”

Fischer MG, Hackl T. Host genome integration and giant virus-induced reactivation of the virophage mavirus. Nature. 2016 Dec 7;540(7632):288-291. doi: 10.1038/nature20593.

January 25, 2017

***Will meet in Genentech Hall N114***

Victoria Cheung
Feinberg Lab

"Hi-Bear-Nation: Brown Bear Energy Metabolism Modulation by Gut Microbiota during Hibernation”

Sommer F, Ståhlman M, Ilkayeva O, Arnemo JM, Kindberg J, Josefsson J, Newgard CB, Fröbert O, Bäckhed F. The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos.  Cell Rep. 2016 Feb 23;14(7):1655-61. doi: 10.1016/j.celrep.2016.01.026. Epub 2016 Feb 4.

Steve Altschuler

"Modeling crowd-sourced scientific belief, and other epistemological BS”

Nissen SB, Magidson T, Gross K, Bergstrom CT. Publication bias and the canonization of false facts. Elife. 2016 Dec 20;5. pii: e21451. doi: 10.7554/eLife.21451.

February 1, 2017

***Will meet in Genentech Hall N114***

Ravi Desai
Weinberger Lab

"A cure for Benjamin Button Disease? Harnessing the Yamanaka factors to reverse aging”
Ocampo A et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell. 2016 Dec 15;167(7):1719-1733.e12. doi: 10.1016/j.cell.2016.11.052.

Yin Shen

"A new level of transcriptional regulation by CBP and enhancer RNA”

Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R, Berger SL. RNA Binding to CBP Stimulates Histone Acetylation and Transcription. Cell. 2017 Jan 12;168(1-2):135-149.e22. doi: 10.1016/j.cell.2016.12.020. Epub 2017 Jan 12.

February 8, 2017

***Will meet in Genentech Hall N114***

Kelsey Hickey
Weissman Lab

"Therapy from thin air? Hypoxia as treatment for mitochondrial disease”

Jain IH et al.  Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 1;352(6281):54-61. doi: 10.1126/science.aad9642. Epub 2016 Feb 25.

Markus Delling

"Shedding the ciliary tip: Is IT the trash can of the primary cilium?”

Nager AR, Goldstein JS, Herranz-Pérez V, Portran D, Ye F, Garcia-Verdugo JM, Nachury MV. An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling. Cell. 2017 Jan 12;168(1-2):252-263.e14. doi: 10.1016/j.cell.2016.11.036. Epub 2016 Dec 22.

February 15, 2017

***Will meet in Genentech Hall N114***

Eliza Nieweglowska
Agard Lab

"Bodacious Bacteria: CrvA Polymer Induces Curved Morphology and Enhances Pathogenesis in Vibrio cholerae

Bartlett TM et al. A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis. Cell. 2017 Jan 12;168(1-2):172-185.e15. doi: 10.1016/j.cell.2016.12.019. Epub 2017 Jan 12.

Robert Edwards

"A Trojan Horse at the Synapse”

Li L et al.  Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation. Neuron. 2016 Dec 7;92(5):1007-1019. doi: 10.1016/j.neuron.2016.10.023. Epub 2016 Nov 10.

February 22, 2017

***Will meet in Genentech Hall N114***

Rebecca McGillivary
Marshall Lab

"A Fairy Circle Ending: A theoretical foundation for multi-scale regular vegetation patterns”

Tarnita CE, Bonachela JA, Sheffer E, Guyton JA, Coverdale TC, Long RA, Pringle RM. A theoretical foundation for multi-scale regular vegetation patterns. Nature. 2017 Jan 18;541(7637):398-401. doi: 10.1038/nature20801.

Andy Chang

"Sensing the urge to breathe”

Kumar NN et al. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. Science. 2015 Jun 12;348(6240):1255-60. doi: 10.1126/science.aaa0922. Epub 2015 Jun 11.