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TETRAD FACULTY
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Regulation of Intracellular Membrane Traffic
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The Brodsky laboratory studies the structure and function of clathrin. Clathrin-coated vesicles participate in receptor-mediated endocytosis and organelle biogenesis. In the immune system they contribute to processing and presentation of antigens and regulate expression of B cell, T cell and natural killer cell recognition receptors. An isoform of clathrin functions in skeletal and cardiac muscle in distinct tissue-specific pathways. Having characterized the basic biochemistry and structure of clathrin, the laboratory is now focusing on regulation of clathrin in cells of the immune system and in muscle and its dysregulation in cancer and muscle disease, as well as its function in eukaryotic infectious organisms.
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| Featured paper | | Identifying phase-specific genes in the fungal pathogen Histoplasma Capsulatum
Sil Lab | | Download the pdf |
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Faculty
