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Alexander (Sandy) Johnson
(1) We study gene repression in the budding yeast S. cerevisiae using a combination of genetic, biochemical genomics, and structural approaches. (2) We study the molecular mechanisms of pathogenesis using the most prevalent human fungal pathogen Candida albicans. Although closely related to S. cerevisiae, Candida has many features that are specialized for interactions with its mammalian hosts; these are the focus of our work. (3) The rewiring of transcriptional circuits is thought to be a major source of evolutionary novelty. Using simple yeasts, we are studying the molecular bases by which transcriptional circuits evolve.