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Pluripotency, the capacity to differentiate into all cell types, is a fundamental property of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Because ESCs and iPSCs can self-renew in the pluripotent state indefinitely, these cells are regarded as a major potential source of material for stem cell-based therapies. However, the mechanisms governing self-renewal and pluripotency are not completely understood. The Panning lab investigates the role of epigenetic regulators, such as enzymes that mediate post-translational modifications and non-coding RNAs, in pluripotent cells.