You are here
Danica Galonić Fujimori
Our lab is interested in mechanistic enzymology, regulation and small molecule-mediated modulation of several post-translational and post-transcriptional modifications crucial to cellular function. Specifically, we are interrogating roles of the reversible methylation of nucleosomes, with the goal of understanding how the jumonji family of histone demethylases regulates transcription in physiology and disease. We are probing the function of these enzymes by studying their catalysis and regulation, and developing chemical tools to perturb their cellular function. Additionally, we have recently identified a unique pathway for ribosome methylation. We are pursuing the mechanistic aspects of this modification and investigating its impact on translation and antibiotic resistance. A third area of investigation in our lab focuses on the role of glycosylation in protein quality control, and the function of carbohydrate acting enzymes in the process.