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The Chang Lab studies fundamental questions concerning spatial organization within a single cell: How is cell shape and size determined. How might cells sense their own size, or their shape? How do mechanical-based mechanisms dictate the growth, size and shape of cells?
To address these questions, we study primarily a simple eukaryotic model organism, the fission yeast Schizosaccharomyces pombe. These are rod-shaped cells that display a highly uniform size and rod-shaped morphology. We seek to elucidate quantitative molecular and biomechanical mechanisms underlying the dynamic cellular processes responsible for cell morphogenesis. We use interdisciplinary approaches, combining the expertise and perspectives of cell biologists, geneticists, physicists, engineers and modelers.
Current projects include: regulation of cell size, mechanical-based mechanism of cell shape determination and cytokinesis, and regulation of microtubule dynamics.