You are here
Our laboratory is focused on tackling fundamental challenges in the precise measurement and analysis of decision making in complex biological networks. We are an exciting mixture of biologists, engineers, physicists and mathematicians who are constantly pushing technological, experimental, and computational boundaries. For example, we use variability between genetically and environmentally identical cells, coupled with quantitative measurement of single cells and rigorous computational modeling, to unravel cellular wiring diagrams and probe their dynamical properties. We develop technologies to monitor dynamic signal propagation across whole networks in single cells with unprecedented precision and scale. We also develop efficient computational tools for the modeling and analysis of spatio-temporal cellular dynamics. We harness the power of these tools to probe coordination and signal integration in cellular stress responses, such as the Environmental Stress Response.