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For cancer to spread, genes involved in the metastatic process must be altered. This dysregulation largely arises from modulations in the regulatory programs that govern gene expression. We are building a multidisciplinary research program aimed at understanding the role of post-transcriptional regulatory pathways in driving cancer progression. First, we address this problem by developing experimental methodologies for the quantification of RNA dynamics in cancer cells. In parallel, we create integrated computational and experimental frameworks that enable the discovery of post-transcriptional regulatory pathways based on the experimental measurements. Ultimately we use our expertise in cancer biology to functionally validate the identified pathways in vitro and in vivo. Our overarching goal is to achieve a detailed understanding of post-transcriptional regulatory networks and their role in human disease. We believe that this knowledge can be effectively leveraged to disrupt the growth and spread of cancer cells.