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B and T lymphocytes migrate hundreds of micrometers each day to survey the body for pathogens. During antibody responses, lymphocytes interact and give rise to germinal center responses that generate high affinity antibodies. The mechanisms controlling these cell behaviors are far from understood. Major goals of our work are to: (i) define the protein and lipid cues that guide cell movements in lymphoid organs; (ii) use intravital microscopy techniques to track cell migration and interaction dynamics; (iii) define how lymphocytes egress from lymphoid organs; (iv) define the mechanism of high affinity B cell selection in germinal centers.