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The most fundamental type of organization of cells in metazoa is that of epithelia. Epithelial cells form sheets of cells that line surfaces and internal cavities. The simplest metazoa, such as hydra, consist largely of two concentric cylinders of epithelial cell sheets. Most internal organs in higher animals, such as the respiratory, digestive, genito-urinary and vascular systems are lined by a single layer of epithelial cells. We are studying the structure and polarity of individual epithelial cells, how they are organized into multicellular tissues and organs, and how these are repaired and regenerate in response to injury. We use cell and organotypic culture, mice and in silico modeling, combining live imaging, biochemistry and genetics.