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Research in my laboratory is focused on the discovery of new chemical based tools to decipher cellular signaling networks with an emphasis on protein kinases. In particular, we have developed chemical tools based on a combination of protein engineering and organic synthesis. We have termed this approach?chemical genetics. The advantage of this method over traditional chemical design approaches is that we rely on genetics to select the target of a small molecule, ensuring that only the intended protein is targeted by the small molecule we synthesize.