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Drosophila sensory neurons tile the larval body wall, Dr. Chun Han

Faculty

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Campus Address: RH, 484F Box: 2811
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(415) 476-8748

Lily Jan

Ion channels

Conserved among eukaryotes and prokaryotes, potassium channels modulate neuronal signaling in the brain and control heart rate, vascular tone, insulin release and the flow of salt across epithelia. Calcium-activated chloride channels (CaCC) also serve a broad range of physiological functions, including the control of secretion from airway epithelia and exocrine glands and rhythmic contraction of the gastrointestinal tract, and regulation of neuronal excitability.

Starting with positional cloning of the Drosophila Shaker voltage-gated potassium (Kv) channel, expression cloning of a mammalian inwardly rectifying potassium (Kir) channel, and the recent expression cloning of Xenopus CaCC, we have been studying the function and regulation of these evolutionarily conserved ion channel families.