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We use the powerful genetics, molecular, and cellular biology of the C. elegans olfactory system to understand how environmental factors alter behavior and to ask how neuronal stimulation alters stem cell pools and the chromatin state of progeny. We are attempting to visualize the RNA content and chromatin state of specific cells in the living, behaving animal. The goal of our work is to uncover the circuits and molecular pathways responsible for these processes. Understanding how neuronal plasticity regulates these processes in C. elegans will reveal how experience might alter mammalian stem cell pools and influence inherited behavioral states.