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We are fascinated with the mechanisms that control timing during development. The earliest stages of development isolate temporal control and the key target of the temporal control is the cell cycle. We study the precise timing of the slowing of the cell cycle and onset of morphogenesis at a major embryonic transition, the mid-blastula transition (MBT), in Drosophila.
In new area we have developed tools to probe the biology of mitochondria and inheritance of mtDNA. We have identified mechanisms that actively enforce uniparental inheritance, and are examining the mechanisms governing which of the numerous mitochondrial genomes is successfully transmitted.