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We are interested to understand the molecular mechanisms underlying RNA viruses (such as picornaviruses and flaviviruses) replication and pathogenesis. We focus in the molecular details of RNA replication, viral protein expression, and RNA packaging. In particular, we are examining the virus interactions with the cellular machinery by identifying cellular factors involved in the virus life cycle. We are also exploring the potential use of these plus-stranded RNA viruses as vaccine vectors to express antigens from other pathogens, including HIV and malaria. More recently, we have initiated studies aiming to evaluate the antiviral potential of RNA interference by focusing in three aspects: the therapeutic potential of RNAi; RNAi as a natural antiviral defense mechanism in animals; and systemic spread of RNAi inhibitory effect.