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At the Stroud lab, scientists seek to understand molecular mechanisms of certain key biological processes, as well as signal transduction between processes at the level of protein structure, dynamics, and mechanism. Three-dimensional molecular structures are defined primarily by x-ray crystallography and are often used to facilitate structure-based drug design, providing a quintessential test of our understanding of the relationship between structure and recognition. Currently the integration enzyme from HIV is subject to molecular biological, biochemical, and structural approaches. The molecular mechanisms of thymidylate synthase are derived from numerous structural studies in the laboratory. An important cancer target, these mechanisms pertain directly to our structure and mechanism based design of anticancer drugs.