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Drosophila sensory neurons tile the larval body wall, Dr. Chun Han

Faculty

Phone: 
(415) 502-0706

Rushika Perera

Reprogramming of cellular metabolic networks in cancer

Our lab studies the mechanisms of autophagy-lysosome activation and the contribution of this organellar system to metabolic reprogramming in cancer. We hypothesize that the functional interplay between cellular trafficking pathways and activation of gene programs that regulate organelle dynamics and function are tightly coupled and essential for tumor growth. Our studies at the intersection of cell biology and cancer research, using a combination of biochemistry, immuno-fluorescence imaging, proteomics and metabolomics in cancer cell lines, primary patient derived culture systems and genetically engineered mouse tumor models, aims to provide insight into how fundamental cellular process are rewired in cancer.