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We are interested in understanding how bacterial proteins subvert host vesicular transport processes and manipulate them to their own advantage. Understanding the mechanisms of host-pathogen interactions serves two main purposes. First, it provides an understanding of the mechanism of disease and thus leads to the development of better therapeutic approaches. Second, because bacteria disrupt host processes in multiple ways and often target key vesicular transport proteins, studying these interactions often lead to a deeper understanding of basic mammalian membrane transport processes.