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Our lab is interested in understanding the fundamental principles by which living cells use molecular signaling networks to make complex behavioral decisions. We study the molecular mechanisms of diverse signaling proteins, complexes and networks. We use a combination of theoretical and experimental approaches to understand the overall logic of how common decision-making circuits operate. We also use synthetic biology approaches to build non-natural signaling networks, as a way to systematically develop and test our understanding of these cellular decision-making systems. Finally we are applying our understanding of network logic to develop platforms to engineer cells with new, custom-designed behaviors, such as cells that execute precision therapeutic or bioproduction functions. We are exploring signaling network function in diverse cell-types, including yeast, immune cells, neurons and multi-cellular systems.