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Journal Club

Journal Club: Wednesdays at 1:00pm in Genentech Hall Auditorium

October 16, 2019

***Will meet in GH N114***

Fred Chang

“Building the cell wall: Mechanosensitive regulation of cell wall thickness"

Davi V., Minc N. et al..  Mechanosensation Dynamically Coordinates Polar Growth and Cell Wall Assembly to Promote Cell Survival. Dev Cell. 2018 Apr 23;45(2):170-182.e7. doi: 10.1016/j.devcel.2018.03.022.

Stephen Floor

“Noise in gene expression: cut it out”

Bryan Sands, Soo Yun, Alexander R. Mendenhall. Introns Control Intrinsic Noise. BioRxiv doi: This article is a preprint and has not been certified by peer review.

October 23, 2019

***Will meet in GH N114***

Elphege Nora

"Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells"

Zhang Y, Ren B, et al.  Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells.  Nat Genet. 2019 Sep;51(9):1380-1388. doi: 10.1038/s41588-019-0479-7. Epub 2019 Aug 19.

Sophie Dumont

“How mammalian oocytes build a spindle without centrosomes”

So C, Schuh M, et al. A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes. Science. 2019 Jun 28;364(6447). pii: eaat9557. doi: 10.1126/science.aat9557.

October 30, 2019

***Will meet in GH N114***

Matt Nalley
Madhani Lab

“How did we get here? scATAC-seq reveals developmental trajectories of cellular differentiation.”

Satpathy AT et al. Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion. Nat Biotechnol. 2019 Aug;37(8):925-936. doi: 10.1038/s41587-019-0206-z. Epub 2019 Aug 2.

Martin Kampmann

“Care packages nurture a long-distance relationship”

Cioni JM et al. Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons. Cell. 2019 Jan 10;176(1-2):56-72.e15. doi: 10.1016/j.cell.2018.11.030. Epub 2019 Jan 3.

November 6, 2019

***Will meet in GH N114***

Megan Chong
Dumont Lab

“Read the room! Migrating amoeboid cells sample their local environment to move along the path of least resistance”

Renkawitz J et al. Nuclear positioning facilitates amoeboid migration along the path of least resistance. Nature. 2019 Apr;568(7753):546-550. doi: 10.1038/s41586-019-1087-5. Epub 2019 Apr 3.

Sarah Heater
Sil Lab

“Anyrin Bacteria to Sea Sponges”

Jahn MT et al. A Phage Protein Aids Bacterial Symbionts in Eukaryote Immune Evasion. Cell Host Microbe. 2019 Oct 9;26(4):542-550.e5. doi: 10.1016/j.chom.2019.08.019. Epub 2019 Sep 24.

November 13, 2019

***Will meet in GH N114***

Lorenzo Del Castillo
Reiter Lab

“Use It or Lose It! ER Hormesis in aging”

Matai L et al. Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17383-17392. doi: 10.1073/pnas.1900055116. Epub 2019 Aug 14.

Jocelyne Lopez
McCormick Lab

“How getting RIDD of Blos1 protects cells from ER stress”

Bae D, Moore KA, Mella JM, Hayashi SY, Hollien J. Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress. J Cell Biol. 2019 Apr 1;218(4):1118-1127. doi: 10.1083/jcb.201809027. Epub 2019 Feb 20.

November 20, 2019

***Will meet in GH N114***

Connie Yan
Marshall Lab

“Finishing a tail: Caudal fin injury responses in larval zebrafish”

Miskolci V et al.  Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish. Elife. 2019 Jul 1;8. pii: e45976. doi: 10.7554/eLife.45976.

Dave Toczyski

“Selfish centromere shenanigans skews segregation”

Akera T, Trimm E, Lampson MA. Molecular Strategies of Meiotic Cheating by Selfish Centromeres. Cell. 2019 Aug 22;178(5):1132-1144.e10. doi: 10.1016/j.cell.2019.07.001. Epub 2019 Aug 8.

December 4, 2019

***Will meet in GH N114***

Lili Kim
Rosenberg Lab

“Playing by the rules of piRNA targeting”

Zhang D, Tu S, Stubna M, Wu WS, Huang WC, Weng Z, Lee HC.  The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes.  Science. 2018 Feb 2;359(6375):587-592. doi: 10.1126/science.aao2840. Epub 2018 Feb 1.

Max Nachury

“Tiger flatworms see the light ... with 421 cilia ... inside a phaosome”

Rawlinson KA et al. Extraocular, rod-like photoreceptors in a flatworm express xenopsin photopigment. Elife. 2019 Oct 22;8. pii: e45465. doi: 10.7554/eLife.45465.

January 15, 2020

***Will meet in GH N114***

Greg Mohl
Kampmann Lab

“Deuterosomes and Parent Centrioles: Who needs them?”

Mercey O. et al.  Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nat Cell Biol. 2019 Dec;21(12):1544-1552. doi: 10.1038/s41556-019-0427-x. Epub 2019 Dec 2.

David Raleigh

“Pediatric Rhabdoid Tumors: Genomically boring, immunologically interesting, and (thankfully) really rare”

Leruste A. et al.  Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors. Cancer Cell. 2019 Dec 9;36(6):597-612.e8. doi: 10.1016/j.ccell.2019.10.008. Epub 2019 Nov 7.

January 22, 2020

***Will meet in GH N114***

Evelyn Hernandez
Irannejad Lab

“Gaining a new mitochondrial zip code via alternative translation initiation”

Monteuuis G et al. Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins. Nucleic Acids Res. 2019 Jun 20;47(11):5777-5791. doi: 10.1093/nar/gkz301.

Pat O'Farrell

“Assessing the impact of genetic conflict”

Luo S. et al. Biparental Inheritance of Mitochondrial DNA in Humans. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13039-13044. doi: 10.1073/pnas.1810946115. Epub 2018 Nov 26.