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Journal Club: Wednesdays at 1:00pm in Genentech Hall Auditorium

September 27, 2017

***Will meet in Genentech Hall N114***

Taylor Skokan
Vale Lab

"Finding closure after a break up:  Identifying a key regulator of nuclear envelope reformation after chromosome segregation”

Samwer M, Schneider MWG, Hoefler R, Schmalhorst PS, Jude JG, Zuber J, Gerlich DW.  DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes. Cell. 2017 Aug 24;170(5):956-972.e23. doi:10.1016/j.cell.2017.07.038.

Hiten Madhani

"Two men say they're Jesus.  One of them must be wrong”

Gladyshev E, Kleckner N. DNA sequence homology induces cytosine-to-thymine mutation by a heterochromatin-related pathway in Neurospora. Nat Genet. 2017 Jun;49(6):887-894. doi: 10.1038/ng.3857. Epub 2017 May 1.

October 4, 2017

***Will meet in Genentech Hall N114***

Paige Haas
Krogan Lab

“Use the Force: Mechanical cues initiate self-organization in avian skin development”
Shyer AE, Rodrigues AR, Schroeder GG, Kassianidou E, Kumar S, Harland RM. Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin. Science. 2017 Aug 25;357(6353):811-815. doi: 10.1126/science.aai7868. Epub 2017 Jul 13.

Sophie Dumont

“On Being Big: Large Cytoplasm Is Linked to the Error-Prone Nature of Oocytes”
Kyogoku H, Kitajima TS. Large Cytoplasm Is Linked to the Error-Prone Nature of Oocytes. Dev Cell. 2017 May 8;41(3):287-298.e4. doi: 10.1016/j.devcel.2017.04.009.

October 11, 2017

***Will meet in Genentech Hall N114***

Senen Mendoza
Bondy-Denomy Lab

“The apple doesn’t fall far from the tree: replication-coupled modification in plants”

Jiang D, Berger F. DNA replication-coupled histone modification maintains Polycomb gene silencing in plants. Science. 2017 Sep 15;357(6356):1146-1149. doi: 10.1126/science.aan4965. Epub 2017 Aug 17.

Joe Bondy-Denomy

“Gene editing without CRISPR! Worm brains figured it out a long time ago”
Deffit SN, Yee BA, Manning AC, Rajendren S, Vadlamani P, Wheeler EC, Domissy A, Washburn MC, Yeo GW, Hundley HA. The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis. Elife. 2017 Sep 19;6. pii: e28625. doi: 10.7554/eLife.28625. [Epub ahead of print]
October 25, 2017

***Will meet in Genentech Hall N114***

Myles Hochman
Goodarzi Lab

“RNA Editing in Cephalopods Linked to Changes in Ink-remential Rate of Genomic Evolution”
Liscovitch-Brauer N, Alon S, Porath HT, Elstein B, Unger R, Ziv T, Admon A, Levanon EY, Rosenthal JJ, Eisenberg E.  Trade-off between Transcriptome Plasticity and Genome Evolution in Cephalopods. Cell. 2017 Apr 6;169(2):191-202.e11. doi: 10.1016/j.cell.2017.03.025.

Bassem Al-Sady

“Never forget the depth of winter: How heterochromatin spreading makes sure you remember”

Yang H, Berry S, Olsson TSG, Hartley M, Howard M, Dean C. Distinct phases of Polycomb silencing to hold epigenetic memory of cold in Arabidopsis. Science. 2017 Sep 15;357(6356):1142-1145. doi: 10.1126/science.aan1121. Epub 2017 Aug 17.

November 1, 2017

Antonio Cuevas-Navarro
McCormick Lab

“One Step Closer to Designer Antlings”

Yan H et al. An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in Ants. Cell. 2017 Aug 10;170(4):736-747.e9. doi: 10.1016/j.cell.2017.06.051.

Martin Kampmann

“This mechanism of selective vulnerability is dope! (amine)”

Burbulla LF et al. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science. 2017 Sep 22;357(6357):1255-1261. doi: 10.1126/science.aam9080. Epub 2017 Sep 7.

November 8, 2017
***Will meet in Genentech Hall N114***

Kristine Trotta
Chou Lab

"Another Runner in the Night: A Novel Strategy for Propagation of Selfish Genetic Elements”

Tiwari B, Kurtz P, Jones AE, Wylie A, Amatruda JF, Boggupalli DP, Gonsalvez GB, Abrams JM. Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational Inheritance. Curr Biol. 2017 Oct 9;27(19):3010-3016.e3. doi: 10.1016/j.cub.2017.08.036. Epub 2017 Sep 28.

Steve Altschuler

“Drug-sensitivity measures that grow better with time”
Hafner M, Niepel M, Chung M, Sorger PK. Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs. Nat Methods. 2016 Jun;13(6):521-7. doi: 10.1038/nmeth.3853. Epub 2016 May 2.
November 15, 2017

***Will meet in Genentech Hall N114***

Chris McGinnis
Gartner Lab

“Optogenetic induction of neuronal differentiation sheds light on how cells distinguish signal from noise during fate selection”

Sokolik C, Liu Y, Bauer D, McPherson J, Broeker M, Heimberg G, Qi LS, Sivak DA, Thomson M. Transcription factor competition allows embryonic stem cells to distinguish authentic signals from noise. Cell Syst. 2015 Aug 26;1(2):117-129.

Todd Nystul

“RNA methylation is the new kid on the block”

Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, Riggs AD, He C, Shi Y. m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells. Cell Rep. 2017 Mar 14;18(11):2622-2634. doi: 10.1016/j.celrep.2017.02.059.
November 29, 2017

***Will meet in Genentech Hall N114***

Bushra Bibi
Joachim Li Lab

“Actin actin-g up in the spindle…Really?”

Mogessie B, Schuh M. Actin protects mammalian eggs against chromosome segregation errors. Science. 2017 Aug 25;357(6353). pii: eaal1647. doi: 10.1126/science.aal1647.

Robert Edwards

“Protein Homeostasis in the Normal State”

Li J, Zhang YV, Asghari Adib E, Stanchev DT, Xiong X, Klinedinst S, Soppina P, Jahn TR, Hume RI, Rasse TM, Collins CA. Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104. Elife. 2017 Sep 19;6. pii: e24271. doi: 10.7554/eLife.24271.

January 17, 2018

***Will meet in Genentech Hall N114***

Adam Longhurst
Toczyski Lab

“Are You With Me or Against Me?: Transcription-Replication Conflicts and Their Consequences for Genome Stability”

Hamperl S, Bocek MJ, Saldivar JC, Swigut T, Cimprich KA. Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses. Cell. 2017 Aug 10;170(4):774-786.e19. doi: 10.1016/j.cell.2017.07.043.

Aashish Manglik

“An old dog with new tricks: multidimensional signaling in receptor tyrosine kinases”

Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, Ferguson KM, Leahy DJ, Lidke DS, Lemmon MA. EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell. 2017 Oct 19;171(3):683-695.e18. doi: 10.1016/j.cell.2017.09.017. Epub 2017 Oct 5.

January 24, 2018

***Will meet in Genentech Hall N114***

Irene Lui
Wells Lab

“Patching the Powerhouse: Identifying new Mitochondrial DNA Repair Machinery”

Wisnovsky S, Jean SR, Kelley SO. Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes. Nat Chem Biol. 2016 Jul;12(7):567-73. doi: 10.1038/nchembio.2102. Epub 2016 May 30.

Orion Weiner

“Morphogenesis and the chamber of secrets”

Durdu S, Iskar M, Revenu C, Schieber N, Kunze A, Bork P, Schwab Y, Gilmour D. Luminal signalling links cell communication to tissue architecture during organogenesis. Nature. 2014 Nov 6;515(7525):120-4. doi: 10.1038/nature13852. Epub 2014 Oct 22.TBA

January 31, 2018

***Will meet in Genentech Hall N114***

Chris Waters
Altschuler/Wu Lab

“Forced (o)pun: how compression of the nucleus affects nuclear pore size and transport dynamics”

Elosegui-Artola A et al.  Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. Cell. 2017 Nov 30;171(6):1397-1410.e14. doi: 10.1016/j.cell.2017.10.008. Epub 2017 Oct 26.

Roshanak Irannejad

“The monomeric act of a heterotrimer”

Solis GP, Bilousov O, Koval A, Lüchtenborg AM, Lin C, Katanaev VL. Golgi-Resident Gαo Promotes Protrusive Membrane Dynamics. Cell. 2017 Sep 7;170(6):1258. doi: 10.1016/j.cell.2017.08.045.

February 7, 2018

***Will meet in Genentech Hall N114***

 Nia Teerikorpi
Willsey Lab
“That’s so RETROtransposon: Neuronal protein Arc forms virus-like capsid structures to transport mRNA between neurons”

Ashley J, Cordy B, Lucia D, Fradkin LG, Budnik V, Thomson T. Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons. Cell. 2018 Jan 11;172(1-2):262-274.e11. doi: 10.1016/j.cell.2017.12.022.

Pastuzyn ED et al.  The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell. 2018 Jan 11;172(1-2):275-288.e18. doi: 10.1016/j.cell.2017.12.024.

February 14, 2018

***Will meet in Genentech Hall N114***

Carlos Nowotny
Agard Lab

“A Rosette by Any Other Name... A Look into the Homeostasis of a Plant Immune Kinase”

Wang J et al. A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase. Mol Cell. 2018 Feb 1;69(3):493-504.e6. doi: 10.1016/j.molcel.2017.12.026. Epub 2018 Jan 18.

Max Nachury

“Feel the force (within the lipid bilayer)!' Mechanical gating by Piezo channels”

Saotome K, Murthy SE, Kefauver JM, Whitwam T, Patapoutian A, Ward AB. Structure of the mechanically activated ion channel Piezo1. Nature. 2017 Dec 20. doi: 10.1038/nature25453. [Epub ahead of print]

February 21, 2018


***Will meet in Genentech Hall N114***

Veronica Escalante
Turnbaugh Lab

“A sticky situation: A chemically modified cellulose makes for stronger bacterial biofilms”

Thongsomboon W, Serra DO, Possling A, Hadjineophytou C, Hengge R, Cegelski L.  Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose. Science. 2018 Jan 19;359(6373):334-338. doi: 10.1126/science.aao4096.

February 28, 2018

***Will meet in Genentech Hall N114***

Hannah Toutkoushian
Walter Lab

“A (Sup)erb pH-sensing domain protects yeast release factor Sup35p from stress-induced damage”

Franzmann TM et al. Phase separation of a yeast prion protein promotes cellular fitness. Science. 2018 Jan 5;359(6371). pii: eaao5654. doi: 10.1126/science.aao5654.

Mark von Zastrow

“A case for regime change... growth factor signaling in cancer”

Pinilla-Macua I, Grassart A, Duvvuri U, Watkins SC, Sorkin A.  EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo. Elife. 2017 Dec 21;6. pii: e31993. doi: 10.7554/eLife.31993.

March 7, 2018

***Will meet in Genentech Hall N114***

Muryam Gourdet
Narlikar Lab

“COP directing new traffic”

Xu P et al. COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal. Elife. 2017 Oct 23;6. pii: e28342. doi: 10.7554/eLife.28342.

Fred Chang

“The pressure is on: DNA may shape bacterial cells mechanically by acting as an osmotic agent”

Lopez-Garrido J, Ojkic N, Khanna K, Wagner FR, Villa E, Endres RG, Pogliano K. Chromosome Translocation Inflates Bacillus Forespores and Impacts Cellular Morphology. Cell. 2018 Feb 8;172(4):758-770.e14. doi: 10.1016/j.cell.2018.01.027.

March 14, 2018

***Will meet in Byers Hall 212***

Veronica Escalante
Turnbaugh Lab

“A sticky situation: A chemically modified cellulose makes for stronger bacterial biofilms”

Thongsomboon W, Serra DO, Possling A, Hadjineophytou C, Hengge R, Cegelski L.  Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose. Science. 2018 Jan 19;359(6373):334-338. doi: 10.1126/science.aao4096.

Markus Delling

“When life gives you lemons, make sure they are sour. Molecular mechanism of acid sensation”

Tu YH et al. An evolutionarily conserved gene family encodes proton-selective ion channels. Science. 2018 Mar 2;359(6379):1047-1050. doi: 10.1126/science.aao3264. Epub 2018 Jan 25.