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Drosophila sensory neurons tile the larval body wall, Dr. Chun Han


Campus Address:, HD 386, Box 3110
(415) 514-9755

Davide Ruggero

How translational control shapes the proteome in normal and cancer cells

We study the basic mechanisms guiding translational control of gene expression. Our work is centered on how translation initiation factors, ribosomal RNA modifications, and a novel set of 5’UTR elements provide a dynamic range of post-transcription regulation to how genes are expressed in time and space. We further exploit how deregulations in translational control lead to a wide spectrum of human diseases including cancer and fetal bone marrow failure to gain a more comprehensive understanding of translational control guiding normal cellular decisions, human disease, and metabolism. We are also designing a new generation of compounds that modulate the cellular proteome and act as cancer therapeutic agents. Our lab employs a convergence of biochemical, molecular, and genetic approaches that enable us to ask these questions both in the test tube and in living organisms.