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Our laboratory uses genetics and genomics to understand the biology of the fungal pathogen Histoplasma capsulatum. First identified in 1906, H. capsulatum is thought to be the most common cause of fungal respiratory infections in the world. Very little is known about H. capsulatum biology. H. capsulatum grows in an infectious filamentous form in the soil, and in a parasitic yeast form in the host. We are investigating how H. capsulatum alters its growth program in response to its environment. In addition, we are studying how H. capsulatum manipulates the mammalian immune system to cause disease.