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We study the transcriptional and epigenetic regulation of heart development and differentiation. With a combination of mouse genetics and stem cell-based genomics approaches, we are deciphering how the genome is set and reset during differentiation, and how defects in these processes contribute to congenital heart disease. Our research encompasses stem cell biology, epigenomics, and mouse genetics. Using these approaches we are discovering exciting modes of regulation that coordinate gene expression during lineage specification and differentiation. We are also deploying advanced mouse genetic tools to understand cardiac lineage commitment in vivo, to understand the origins of the heart.