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Brains, muscles, hearts, and senses all require electrical signals to function properly. Our laboratory seeks to understand ion channels, the basic components of excitable cells that are responsible for generating electrical activity. To this end, we employ integrated approaches that span from X-ray crystallographic studies of ion channels and ion channel regulator proteins to the development of reagents that manipulate ion channel function. Through these efforts, we aim to define the molecular transformations that underlie how ion channels function as macromolecular complexes and to develop compounds that capitalize on this knowledge to control channel function in vitro and in vivo.