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Despite tremendous complexity, neural circuits in the brain can also be modified as the basis for our ability to learn and adapt to our environment. How is plasticity within the nervous system controlled so that change remains constructive rather than destructive? We are trying to define, at a cellular and molecular level, how stabile neural function is maintained despite the continual modification of neural circuitry. We combine Drosophila genetics/genomics with electrophysiology and quantitative live imaging to identify genes that, when knocked down or mutated, cause neural instability and degeneration, processes directly related to the cause and progression of neural disease.