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My laboratory is interested understanding the complex interplay between microbial pathogens and their host eukaryotic cells, a field that has only recently come into its own recognition and is referred to as cellular microbiology. To that end, we have combined the techniques of eukaryotic cell biology with microbial genetics to investigate the key processes of microbial attachment and entry, intracellular survival, and host cell injury in the context of two important human pathogens, Pseudomonas aeruginosa and Chlamydia trachomatis. Each of these microorganisms has developed a unique strategy for successful survival that involves subverting and exploiting host cell pathways. Dissecting these processes will allow the development of new diagnostics, therapeutics, and vaccines and will provide a unique window into eukaryotic cell biology.