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Our lab is interested in understanding the fundamental principles underlying cell-fate decisions. We take a unique approach using viruses as model systems, since viruses undergo simplified bifurcations between alternate fates (e.g. active vs. latent). Using a coupled computational-experimental approach, which relies on quantitative time-lapse microscopy and mathematical modeling, we probe the transcriptional circuits that regulate these alternate fates at the single-cell level. Ultimately, our goal is to discover new regulatory principles to enable a next-generation of therapeutics that can re-direct viruses and cells down alternate developmental paths.