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Drosophila sensory neurons tile the larval body wall, Dr. Chun Han

Faculty

Office: 
10 Koret Way, 231 Box 0730
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(415) 476-6758

Maxence Nachury

Trafficking and signaling at the primary cilium

We study the primary cilium, a surface-exposed organelle required for vision, olfaction and developmental signaling. Our lab is interested in the mechanisms of trafficking in and out of cilia and how trafficking decisions impact signaling at the cilium. One research axis focuses on Bardet-Biedl Syndrome (BBS), a ciliopathy characterized by obesity, skeletal malformations and kidney cysts. The BBSome is an evolutionarily conserved complex of 8 BBS proteins that traffics signaling receptors out of cilia and we aim to decipher the molecular details of BBSome-mediated trafficking and the cellular, biochemical and structural level. A second research direction is aimed at cilia-derived extracellular vesicles (EVs). Ciliary signaling receptors that fail conventional exit are packaged into ciliary EVs. By dissecting the mechanisms of ciliary EV biogenesis, we will gain insight into the roles of these extracellular parcels in cell-cell communication.