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Signal transduction networks can be wide and complex, but yet are always precisely controlled to assure proper cell division, differentiation and motility. At the heart of their regulation lie protein kinases that generate critical post-translational events and set up regulatory feedback mechanisms that control signaling. An astounding diversity of the molecular mechanisms that control function of protein kinases surprises us all the time about the ways by which kinases control signal transduction. My group focuses on understanding these mechanisms by gaining structural and functional insights into the function of protein kinases and their feedback regulators. To accomplish this, we combine experimental methods such as X-ray crystallography, single particle EM, enzyme biochemistry and cell-based imaging and signaling assays.