University of California, San Francisco  |  About UCSF  |  Search UCSF  |  UCSF Medical Center

You are here

Drosophila sensory neurons tile the larval body wall, Dr. Chun Han

Faculty

Office: 
Campus Address: GH, N-272B Box: 2140
Phone: 
(415) 502-5687

Courses Taught

Robert Edwards

Neurotransmitter Release

We wish to understand the cellular and molecular mechanisms that regulate neurotransmitter release and how they contribute to normal physiology, behavior and disease.  The lab uses a combination of biochemistry in vitro, optical imaging in primary neuronal culture and genetic manipulation in vivo, and focuses on several fundamental questions:  what regulates the amount of transmitter per synaptic vesicle?  what is the molecular basis for different synaptic vesicle pools?  what is the role of glutamate co-release by monoamine neurons?  what mechanisms mediate sorting of proteins to a regulated secretory pathway?  what is the role of dendritic release?  and how does synaptic function (and the Parkinson’s disease-associated protein synuclein in particular) contribute to neural degeneration?