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Development of the neocortex and hippocampus is a highly ordered process with a number of important steps. Cells must be directed to the proper fate in the ventricular zone, must migrate to the appropriate laminar location once born and must establish connectivity with their targets. Many patients with epilepsy or congenital brain malformations have morphologic abnormalities consistent with defects in the control of cell fate, neuronal migration or axon guidance in the developing telencephalon. Our research focuses on several distinct aspects of the regulation of neuronal cell fate, migration and axon guidance using the developing hippocampus as the model system. We are using a broad array of embryologic and molecular genetic techniques to understand these processes in the normal developing state as well as in animals with developmental anomalies.