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Extremely complex structures and function of multi-cellular systems develop through non-steady state reactions. These reactions orchestrate differentiation and integration of different cell types. Our group collaboratively explores developmental plans for organogenesis by investigating the mechanisms involved in the regulation of cell shape and function during early morphogenesis and patterning of vertebrate embryos. We are currently addressing the dynamic interactions governing embryogenesis through cell height regulation, induction and patterning of early midline body axis, and organogenesis of the heart, eye, and central nervous system.