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Our laboratory primarily uses the Drosophila ovary as a model for studying the fundamental properties of epithelial stem cells, their associated niche, and the connection between epithelial stem cells and cancer. We are interested in questions such as: How is stem cell fate maintained within a dynamic epithelial tissue? What is the nature of the epithelial stem cell niche? What is the role of epithelial stem cells in reproductive physiology? How is a healthy population of stem cells maintained throughout adult life? What can studies of epithelial stem cells teach us about the earliest steps in cancer formation?