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Drosophila sensory neurons tile the larval body wall, Dr. Chun Han

Faculty

Office: 
Campus Address: PH, HSW-1321 Box: 0452
Phone: 
(415) 476-4622

Zena Werb

Functional Genomics of Extracellular Proteolysis in Development and Cancer

Our laboratory uses functional genomic approaches to define the role of proteolysis in controlling cell fate decisions, cell survival, vasculogenesis, inflammation and angiogenesis during development and tumorigenesis. Matrix metalloproteinases play a critical role by regulating extracellular matrix and cell surface proteins, growth and angiogenic factors, cell recruitment, cell proliferation and apoptosis. We wish to determine the identity and function of the critical proteinases, how their expression and activities are regulated, what the molecular and cellular targets of the proteinases are, and how these regulate the signaling pathways.