Journal Club

Wed
19

Journal Club

January
1:00 pm

GH N114 (indoor masking required) and Class Capture

Melissa Mendez
Walter Lab

“Not ready for this jelly: ER transmembrane proteins cause extreme curves”

Wang N, Clark LD, Gao Y, Kozlov MM, Shemesh T, Rapoport TA. Mechanism of membrane-curvature generation by ER-tubule shaping proteins. Nat Commun. 2021 Jan 25;12(1):568. PMID: 33495454; PMCID: PMC7835363.

 
Barbara Panning
 
"A TETylating link between glucose metabolism and acetylation"
 
Zhang C, Zhong T, Li Y, Li X, Yuan X, Liu L, Wu W, Wu J, Wu Y, Liang R, Xie X, Kang C, Liu Y, Lai Z, Xiao J, Tang Z, Jin R, Wang Y, Xiao Y, Zhang J, Li J, Liu Q, Sun Z, Zhong J. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. Elife. 2021 Nov 5;10:e70672. PMID: 34738906; PMCID: PMC8592569.

Wed
12

Journal Club

January
1:00 pm

GH N114 (indoor masking required) and Class Capture

Brandon Courteau
Jura/Verba Lab

“It’s Not Just a Phase Mom: Phase separation of a critical phosphatase promotes MAPK activation”

Zhu G, Xie J, Kong W, Xie J, Li Y, Du L, Zheng Q, Sun L, Guan M, Li H, Zhu T, He H, Liu Z, Xia X, Kan C, Tao Y, Shen HC, Li D, Wang S, Yu Y, Yu ZH, Zhang ZY, Liu C, Zhu J. Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation. Cell. 2020 Oct 15;183(2):490-502.e18. Epub 2020 Sep 30. PMID: 33002410; PMCID: PMC7572904.
 
Martin Kampmann
 
"Sweet old brain: In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain"
 
Ruetz et al. In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain. bioRxiv 2021.11.23.469762.
 
 
 
 
 
Wed
08

Journal Club

December
1:00 pm

GH N114 (subject to 50% capacity limit, indoor masking) and Class Capture

Camila Benitez
Kao Lab

“Eating Tau Much: Microglia become hypofunctional after phagocytosing neurons with tau aggregates”

Brelstaff JH, Mason M, Katsinelos T, McEwan WA, Ghetti B, Tolkovsky AM, Spillantini MG. Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates. Sci Adv. 2021 Oct 22;7(43):eabg4980. Epub 2021 Oct 20. PMID: 34669475; PMCID: PMC8528424.

 

Steven Sun

“When Darwin meets Perutz: the Evolution of Modern Hemoglobin”

Pillai AS, Chandler SA, Liu Y, Signore AV, Cortez-Romero CR, Benesch JLP, Laganowsky A, Storz JF, Hochberg GKA, Thornton JW. Origin of complexity in haemoglobin evolution. Nature. 2020 May;581(7809):480-485. Epub 2020 May 20. Erratum in: Nature. 2020 Jul;583(7816):E26. PMID: 32461643; PMCID: PMC8259614.
Wed
01

Journal Club

December
1:00 pm

GH N114 (subject to 50% capacity limit, indoor masking) and Class Capture

LauraAnn Schmidberger
Booth Lab

“What sponge insides can tell us about brain evolution”

Musser JM et al. Profiling cellular diversity in sponges informs animal cell type and nervous system evolution. Science. 2021 Nov 5;374(6568):717-723. Epub 2021 Nov 4. PMID: 34735222.

 

Danica Fujimori

“NotoriouSly Dangerous: Unwrapping nucleosomes to promote cancer”

Li W, Tian W, Yuan G, Deng P, Sengupta D, Cheng Z, Cao Y, Ren J, Qin Y, Zhou Y, Jia Y, Gozani O, Patel DJ, Wang Z. Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature. 2021 Feb;590(7846):498-503. Epub 2020 Dec 23. PMID: 33361816; PMCID: PMC7889650.
Wed
17

Journal Club

November
1:00 pm

GH N114 (subject to 50% capacity limit, indoor masking) and Class Capture

Camille Moore
Ramani/Narlikar Lab

“Cut the Crap: Zoonotic diets, caloric restriction, and colonization resistance”

von Schwartzenberg RJ, Bisanz JE, Lyalina S, Spanogiannopoulos P, Ang QY, Cai J, Dickmann S, Friedrich M, Liu SY, Collins SL, Ingebrigtsen D, Miller S, Turnbaugh JA, Patterson AD, Pollard KS, Mai K, Spranger J, Turnbaugh PJ. Caloric restriction disrupts the microbiota and colonization resistance. Nature. 2021 Jul;595(7866):272-277. Epub 2021 Jun 23. PMID: 34163067.

 

Qili Liu

“Lonely flies eat more and sleep less”

Li W, Wang Z, Syed S, Lyu C, Lincoln S, O'Neil J, Nguyen AD, Feng I, Young MW. Chronic social isolation signals starvation and reduces sleep in Drosophila. Nature. 2021 Sep;597(7875):239-244. Epub 2021 Aug 18. PMID: 34408325; PMCID: PMC8429171.
Wed
10

Journal Club

November
1:00 pm

GH N114 (subject to 50% capacity limit, indoor masking) and Class Capture

Carla Espinoza
Jura Lab

“PIP PIP Hooray! PIPs stabilize GPCR-arrestin complex”

Janetzko J, Kise R, Barsi-Ryne B, Siepe DH, Heydenreich FM, Masureel M, Kawakami K, Garcia KC, von Zastrow M, Inoue A, Kobilka BK. Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics. BioRxiv.2021.   https://doi.org/10.1101/2021.10.09.463790

 

Vanna Tran
Dumont Lab

“Preventing aneuploidy: Waiting until parental chromosomes are ready”

Mori M, Yao T, Mishina T, Endoh H, Tanaka M, Yonezawa N, Shimamoto Y, Yonemura S, Yamagata K, Kitajima TS, Ikawa M. RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization. J Cell Biol. 2021 Oct 4;220(10):e202012001. pub 2021 Aug 23. PMID: 34424312; PMCID: PMC8404465.

 

Wed
03

Journal Club

November
1:00 pm

GH N114 (subject to 50% capacity limit, indoor masking) and Class Capture

Zach Cogan
Walter Lab

“PERKing up translation during chronic ER stress”

Guan BJ, van Hoef V, Jobava R, Elroy-Stein O, Valasek LS, Cargnello M, Gao XH, Krokowski D, Merrick WC, Kimball SR, Komar AA, Koromilas AE, Wynshaw-Boris A, Topisirovic I, Larsson O, Hatzoglou M. A Unique ISR Program Determines Cellular Responses to Chronic Stress. Mol Cell. 2017 Dec 7;68(5):885-900.e6. PMID: 29220654; PMCID: PMC5730339.

 

David Raleigh

“Moving past cancer genomics: Proteomics FTW”

Swaney DL et al. A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. Science. 2021 Oct;374(6563):eabf2911. Epub 2021 Oct 1. PMID: 34591642.

Wed
27

Journal Club

October
1:00 pm

GH N114 (subject to 50% capacity limit, indoor masking) and Class Capture

Claire Kokontis
Bondy-Denomy Lab

“Hijack of CRISPR defenses by selfish genes”

Klompe SE, Vo PLH, Halpin-Healy TS, Sternberg SH. Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration. Nature. 2019 Jul;571(7764):219-225. Epub 2019 Jun 12. PMID: 31189177.

 

Bassem Al-Sady

“Pathogen mimicry goes just too far: Tales of viruses with fat genomes and tiny nucleosomes”

Liu Y, Bisio H, Toner CM, Jeudy S, Philippe N, Zhou K, Bowerman S, White A, Edwards G, Abergel C, Luger K. Virus-encoded histone doublets are essential and form nucleosome-like structures. Cell. 2021 Aug 5;184(16):4237-4250.e19. Epub 2021 Jul 22. PMID: 34297924; PMCID: PMC8357426.

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