Journal Club Talk 12/08/21

Event Date: 
Wednesday, December 8, 2021 - 1:00pm

GH N114 (subject to 50% capacity limit, indoor masking) and Class Capture

Camila Benitez
Kao Lab

Eating Tau Much: Microglia become hypofunctional after phagocytosing neurons with tau aggregates

Brelstaff JH, Mason M, Katsinelos T, McEwan WA, Ghetti B, Tolkovsky AM, Spillantini MG. Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates. Sci Adv. 2021 Oct 22;7(43):eabg4980. Epub 2021 Oct 20. PMID: 34669475; PMCID: PMC8528424.

 

Steven Sun

When Darwin meets Perutz: the Evolution of Modern Hemoglobin

Pillai AS, Chandler SA, Liu Y, Signore AV, Cortez-Romero CR, Benesch JLP, Laganowsky A, Storz JF, Hochberg GKA, Thornton JW. Origin of complexity in haemoglobin evolution. Nature. 2020 May;581(7809):480-485. Epub 2020 May 20. Erratum in: Nature. 2020 Jul;583(7816):E26. PMID: 32461643; PMCID: PMC8259614.