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Drosophila sensory neurons tile the larval body wall, Dr. Chun Han


Campus Address: K-235 Box: 0730
(415) 476-3592

Doug Gould

Cell-matrix interactions and disease

My lab uses genetic approaches to understand complex human diseases. Our goal is to understand primary disease processes and develop targeted therapeutic interventions. We identified that mice with a Col4a1 mutation have pathology in multiple tissues including the lung, kidney, eye and brain. We found COL4A1 mutations in human patients with a spectrum of cerebrovascular diseases and hypothesize that Cesarean delivery of children with COL4A1 mutations could prevent death and life-long disability. We continue to use an array of genetic tools (conditional mutations, modifier screens etc.) to understand developmental (ie. ocular dysgenesis) and age-related human diseases (macular degeneration and hemorrhagic stroke).