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Drosophila sensory neurons tile the larval body wall, Dr. Chun Han


Campus Address: RH, 284E Box: 2611
(415) 476-2731

Holly Ingraham

Transcriptional regulators in energy balance
We focus on development of neuroendocrine regions in the brain that contribute to neural networks of energy balance and reproduction. Our lab uses broad approaches to tackle this question ranging from mouse genetics to the structural biology of NR5A nuclear receptors that specify cell fate in the hypothalamus. Because the hypothalamus is still poorly understood, our efforts have been to define new markers for this brain region using RNA profiling and a genetic screen in zebrafish (with H. Baier). We are also exploring the role of SUMO conjugation and nuclear phosphatidyl inositol (PI) sensing by NR5A nuclear receptors using biochemistry and X-ray crystallography