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Drosophila sensory neurons tile the larval body wall, Dr. Chun Han


GH, N-372E Box 2200
(415) 514-1381

Joseph Bondy-Denomy

CRISPR-Cas Biology and Phage-Bacteria Interactions

Our lab is interested in the molecular arms race between microbes and their viruses, which is likely the most ancient of host-pathogen interactions. Bacteriophages (phages) are the most abundant biological entities on the planet and utilize their genetic armament to manipulate bacteria. Bacterial immune pathways such as CRISPR-Cas systems are among the many fundamental discoveries and biotechnological tools uncovered by studying phage biology. We view these immune systems through the lens of the phage, attempting to understand the “counter-attack” that phages launch against their hosts. We hope to tap into the “dark matter” of the viral world and utilize previously uncharacterized phage genes to discover new fundamental aspects of bacterial life.