University of California, San Francisco  |  About UCSF  |  Search UCSF  |  UCSF Medical Center

You are here

Drosophila sensory neurons tile the larval body wall, Dr. Chun Han


Campus Address: GH, N-312E Box: 2200
(415) 476-6380

Ron Vale

Molecular Motors

The Vale Lab combines cell biological and biophysical approaches to understand the cytoskeleton and more general issues on spatial organization and movement within cells. The lab, which relies heavily on microscopy, studies these questions at different scales and using different techniques. At the smallest scale, we wish to understand the workings of protein machines. A particular focus has been on microtubule-based "motor proteins", 10-50 nm size proteins, that convert energy from ATP hydrolysis into unidirectional motion and force. However, we also are studying the mechanism of other types of proteins, such as microtubule severing proteins, proteins that localize dynamically to growing plus ends of microtubules (+TIPs), and motor regulatory proteins.