Journal Club

Wed
16

Journal Club

March
1:00 pm

CJ San Felipe
Fraser Lab

“The Real SLiM Shady? Sequence- and chemical specificity define the functional landscape of intrinsically disordered regions”


Iris Langstein-Skora, Andrea Schmid, Ryan J. Emenecker, Mary O.G. Richardson, Maximilian J. Götz, Sarah K. Payer, Philipp Korber, Alex S. Holehouse. Sequence- and chemical specificity define the functional landscape of intrinsically disordered regions. bioRxiv 2022.02.10.480018
 
Margaux Pinney
 
"Breaking the Code: tryptophan depletion results in tryptophan-to-phenylalanine substitutants"
 
Pataskar, A., Champagne, J., Nagel, R. et al. Tryptophan depletion results in tryptophan-to-phenylalanine substitutants. Nature (2022).

Wed
09

Journal Club

March
1:00 pm

Candace Chan
Ahituv Lab

“Knowing when to fold: Exploring association of G4s in promoters and transcriptional activity ”


Shen J, Varshney D, Simeone A, Zhang X, Adhikari S, Tannahill D, Balasubramanian S. Promoter G-quadruplex folding precedes transcription and is controlled by chromatin. Genome Biol. 2021 May 7;22(1):143. PMID: 33962653; PMCID: PMC8103603.
 
Andrew Yang
 
"Building a better home for the brain"
 
Martin M et al. Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science. 2022 Feb 18;375(6582):eabm4459. Epub 2022 Feb 18. PMID: 35175798.

Wed
02

Journal Club

March
1:00 pm

Addie Dwyer Cady
Raleigh Lab

“Employing proteomics to improve targeted brain cancer therapies”


Petralia F et al; Children’s Brain Tumor Network; Clinical Proteomic Tumor Analysis Consortium. Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer. Cell. 2020 Dec 23;183(7):1962-1985.e31. Epub 2020 Nov 25. PMID: 33242424; PMCID: PMC8143193.
 
Abby Buchwalter
 
"When stiffness is a signal: mechanical signaling from the extracellular matrix to the nuclear lamina controls Wnt signaling and cell fate"
 
Tang Y, Zhu L, Cho JS, Li XY, Weiss SJ. Matrix remodeling controls a nuclear lamin A/C-emerin network that directs Wnt-regulated stem cell fate. Dev Cell. 2022 Feb 4:S1534-5807(22)00040-5. Epub ahead of print. PMID: 35150612.

Wed
23

Journal Club

February
1:00 pm

Trase Aguigam
J. Gross/Narlikar Lab

“What’s the FUS? Paramagnetic spectroscopy reveals compaction of the RNA-binding protein FUS upon phase separation.”


Emmanouilidis L, Esteban-Hofer L, Damberger FF, de Vries T, Nguyen CKX, Ibáñez LF, Mergenthal S, Klotzsch E, Yulikov M, Jeschke G, Allain FH. NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation. Nat Chem Biol. 2021 May;17(5):608-614. Epub 2021 Mar 8. PMID: 33686294.
 
Todd Nystul
 
"O, wind, if winter comes, can spring be far behind?"
 
Easwaran S, Van Ligten M, Kui M, Montell DJ. Enhanced germline stem cell longevity in Drosophila diapause. Nat Commun. 2022 Feb 7;13(1):711. PMID: 35132083.

Wed
16

Journal Club

February
1:00 pm

Alexis Villani
Bondy-Denomy Lab

“My PriON will go ON: A prion's epigenetic role in an active chromatin state”


Harvey ZH, Chakravarty AK, Futia RA, Jarosz DF. A Prion Epigenetic Switch Establishes an Active Chromatin State. Cell. 2020 Mar 5;180(5):928-940.e14. Epub 2020 Feb 27. PMID: 32109413; PMCID: PMC7195540.
 
Armando Martinez
McCormick Lab
 
"Good Cop, Bad Cop. Cop1 modulates macrophage infiltration"
 
Xiaoqing Wang et al. In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target. bioRxiv 2020.12.09.418012.

Wed
09

Journal Club

February
1:00 pm

GH N114 (indoor masking required) and Class Capture

CJ Sarabia
Irannejad Lab

“Matter Over Mind: How the cellular mechano-environment influences nuclear organization and cellular differentiation”


Seelbinder B, Ghosh S, Schneider SE, Scott AK, Berman AG, Goergen CJ, Margulies KB, Bedi KC Jr, Casas E, Swearingen AR, Brumbaugh J, Calve S, Neu CP. Nuclear deformation guides chromatin reorganization in cardiac development and disease. Nat Biomed Eng. 2021 Dec;5(12):1500-1516. Epub 2021 Dec 2. PMID: 34857921.
 

Babak Javid

“Moonlighting as the day job? Non-translation functions of the multi-synthase complex”


Cui H, Kapur M, Diedrich JK, Yates JR, Ackerman SL, Schimmel P. Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complex. Nucleic Acids Res. 2021 Apr 19;49(7):3603-3616. PMID: 33341895; PMCID: PMC8053116.

Wed
02

Journal Club

February
1:00 pm

GH N114 (indoor masking required) and Class Capture

Kim Meneses
Gartner Lab

“To 3D or not to 3D: the new wave of tissue imaging”


Kuett, L., Catena, R., Özcan, A. et al. Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment. Nat Cancer 3, 122–133 (2022).
 
Joe Bondy-Denomy
 
"Hot Cell Death FTW"
 
Johnson AG, Wein T, Mayer ML, Duncan-Lowey B, Yirmiya E, Oppenheimer-Shaanan Y, Amitai G, Sorek R, Kranzusch PJ. Bacterial gasdermins reveal an ancient mechanism of cell death. Science. 2022 Jan 14;375(6577):221-225. Epub 2022 Jan 13. PMID: 35025633.

Wed
26

Journal Club

January
1:00 pm

GH N114 (indoor masking required) and Class Capture

Alex Hong
Bondy-Denomy Lab

“Cat got your tongue?: Toxoplasma gondii latent infection is maintained by bradyzoite's type I interferon suppression”

Seizova S, Ruparel U, Garnham AL, Bader SM, Uboldi AD, Coffey MJ, Whitehead LW, Rogers KL, Tonkin CJ. Transcriptional modification of host cells harboring Toxoplasma gondii bradyzoites prevents IFN gamma-mediated cell death. Cell Host Microbe. 2021 Dec 16:S1931-3128(21)00518-7. Epub ahead of print. PMID: 34921775.

 
Max Nachury
 
"Shaking the dogma from within: is there local protein synthesis inside cilia?"
 
Hao K, Chen Y, Yan X, Zhu X. Cilia locally synthesize proteins to sustain their ultrastructure and functions. Nat Commun. 2021 Nov 30;12(1):6971. PMID: 34848703; PMCID: PMC8632896.

 

Wed
19

Journal Club

January
1:00 pm

GH N114 (indoor masking required) and Class Capture

Melissa Mendez
Walter Lab

“Not ready for this jelly: ER transmembrane proteins cause extreme curves”

Wang N, Clark LD, Gao Y, Kozlov MM, Shemesh T, Rapoport TA. Mechanism of membrane-curvature generation by ER-tubule shaping proteins. Nat Commun. 2021 Jan 25;12(1):568. PMID: 33495454; PMCID: PMC7835363.

 
Barbara Panning
 
"A TETylating link between glucose metabolism and acetylation"
 
Zhang C, Zhong T, Li Y, Li X, Yuan X, Liu L, Wu W, Wu J, Wu Y, Liang R, Xie X, Kang C, Liu Y, Lai Z, Xiao J, Tang Z, Jin R, Wang Y, Xiao Y, Zhang J, Li J, Liu Q, Sun Z, Zhong J. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. Elife. 2021 Nov 5;10:e70672. PMID: 34738906; PMCID: PMC8592569.

Wed
12

Journal Club

January
1:00 pm

GH N114 (indoor masking required) and Class Capture

Brandon Courteau
Jura/Verba Lab

“It’s Not Just a Phase Mom: Phase separation of a critical phosphatase promotes MAPK activation”

Zhu G, Xie J, Kong W, Xie J, Li Y, Du L, Zheng Q, Sun L, Guan M, Li H, Zhu T, He H, Liu Z, Xia X, Kan C, Tao Y, Shen HC, Li D, Wang S, Yu Y, Yu ZH, Zhang ZY, Liu C, Zhu J. Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation. Cell. 2020 Oct 15;183(2):490-502.e18. Epub 2020 Sep 30. PMID: 33002410; PMCID: PMC7572904.
 
Martin Kampmann
 
"Sweet old brain: In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain"
 
Ruetz et al. In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain. bioRxiv 2021.11.23.469762.
 
 
 
 
 

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